Journal
JOURNAL OF IMMUNOLOGY
Volume 185, Issue 7, Pages 4148-4153Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1001536
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Funding
- National Institutes of Health [HL087870, CA123855, AI43552, CA104596]
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Regulatory T cells (Tregs) are committed to suppressive functions. Recently, it was proposed that Tregs could produce IL-17 under proinflammatory, polarizing conditions. We studied the role of Tregs on IL-17 production in the absence of exogenous cytokines and insults. Using in vitro and in vivo approaches, we determined that under neutral conditions, simultaneous activation of Tregs and naive CD4(+) conventional T cells in the presence of APCs resulted in conversion of Tregs into IL-17-producing cells, and endogenous IL-1 beta was mandatory in this process. Mechanistic analysis revealed that the IL-1R1 was highly expressed on Tregs and that IL-1b induced marked activation of p38 and JNK, which were involved in IL-17 production. These observations could have important implications on therapeutic strategies using Tregs. The Journal of Immunology, 2010, 185: 4148-4153.
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