Journal
JOURNAL OF IMMUNOLOGY
Volume 185, Issue 5, Pages 2783-2789Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1001431
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- Wellcome Trust
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Protective Th1 responses to Salmonella enterica do not develop in the absence of B cells. Using chimeric mice, we dissect the early (innate) and late (cognate) contributions of B cells to Th programming. B cell-intrinsic MyD88 signaling is required for primary effector Th1 development, whereas Ag-specific BCR-mediated Ag presentation is necessary for the development of memory Th1 populations. Programming of the primary T cell response is BCR/B cell MHC II independent, but requires MyD88-dependent secretion of cytokines by B cells. Chimeras in which B cells lack IFN-gamma or IL-6 genes make impaired Th1 or Th17 responses to Salmonella. The Journal of Immunology, 2010, 185: 2783-2789.
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