Analysis of γδ T Cell Functions in the Mouse

Mouse models of disease and injury have been invaluable in investigations of the functional role of gamma delta T cells. They show that gamma delta T cells engage in immune responses both early and late, that they can function both polyclonally and as peripherally selected clones, and that they can be effector cells and immune regulators. They also suggest that functional development of gamma delta T cells occurs step-wise in thymus and periphery, and that it is governed by gamma delta TCR-signaling and other signals. Finally, they indicate that gamma delta T cell functions often segregate with TCR-defined subsets, in contrast to conventional T cells. From the functional studies in mice and other animal models, gamma delta T cells emerge as a distinct lymphocyte population with a unique and broad functional repertoire, and with important roles in Ab responses, inflammation and tissue repair. They also are revealed as a potentially useful target for immune intervention. The Journal of Immunology, 2010, 184: 4055-4061.