Journal
JOURNAL OF IMMUNOLOGY
Volume 185, Issue 4, Pages 2004-2008Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1001176
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Funding
- NIAID NIH HHS [R56 AI081789-01, R56 AI081789, R01 AI073707-04, R01 AI073707] Funding Source: Medline
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Recent evidence demonstrating that exposure to rapamycin during viral infection increased the quantity and quality of Ag-specific T cells poses an intriguing paradox, because rapamycin is used in transplantation to dampen, rather than enhance, donor-reactive T cell responses. In this report, we compared the effects of rapamycin on the Ag-specific T cell response to a bacterial infection versus a transplant. Using a transgenic system in which the Ag and the responding T cell population were identical in both cases, we observed that treatment with rapamycin augmented the Ag-specific T cell response to a pathogen, whereas it failed to do so when the Ag was presented in the context of a transplant. These results suggest that the environment in which an Ag is presented alters the influence of rapamycin on Ag-specific T cell expansion and highlights a fundamental difference between Ag presented by an infectious agent as compared with an allograft. The Journal of Immunology, 2010, 185: 2004-2008.
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