Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 20, Issue 2, Pages 495-502Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.5b00308
Keywords
-
Categories
Funding
- Pierre Fabre
- School of Chemistry, Cardiff University
Ask authors/readers for more resources
The safe use of diazo reagents for the preparation of a key structure in the synthesis of milnacipran analogues is described herein. Using continuous flow technology, the diazo reagent is synthesized, purified, dried, and subsequently used in semi-batch mode for an intramolecular cyclopropanation. Side products formed in the reaction are isolated and rationalized to optimize the process. Different separation techniques in flow are compared with regard to their ability to produce pure and dry diazo reagents. The studies yield a scalable process to a key intermediate in the syntheses of milnacipran and its possible substituted analogues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available