Journal
JOURNAL OF IMMUNOLOGY
Volume 185, Issue 8, Pages 4625-4632Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1001480
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Funding
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/H001085/1]
- BBSRC [BB/H001085/1] Funding Source: UKRI
- MRC [G0501963] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H001085/1] Funding Source: researchfish
- Medical Research Council [G0501963] Funding Source: researchfish
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Estimates of human alpha beta TCR diversity suggest that there are <10(8) different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the pMHC. In this study, we show that the CD8 coreceptor controls T cell cross-reactivity for pMHCI Ags, thereby ensuring that the peripheral T cell repertoire is optimally poised to negotiate the competing demands of responsiveness in the face of danger and quiescence in the presence of self. The Journal of Immunology, 2010, 185: 4625-4632.
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