Journal
JOURNAL OF IMMUNOLOGY
Volume 185, Issue 12, Pages 7156-7160Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1002781
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Funding
- National Institutes of Health
- Pennsylvania Department of Health
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Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial gamma delta T cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissue-specific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions. The Journal of Immunology, 2010, 185: 7156-7160.
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