Journal
JOURNAL OF IMMUNOLOGY
Volume 184, Issue 7, Pages 3331-3335Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0903022
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Funding
- National Cancer Institute and National Institutes of Health [HHSN261200800001E]
- National Cancer Institute
- National Institutes of Health
- National Basic Research Program of China [2010CB529701]
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The formylpeptide receptor-like 1, now officially termed FPR2, in human and its mouse homolog mFPR2 mediate leukocyte migration in response to agonists associated with inflammation and immune responses. To clarify the in vivo role of the receptor, we generated mice deficient in mFPR2. mFPR2(-/-) mice showed markedly reduced severity in OVA/alum-induced allergic airway inflammation. This was associated with diminished recruitment of CD11c(+) dendritic cells into the airway mucosa and secondary lymphoid organs, as well as reduced production of Type 2 cytokines and Igs. We also found that the bronchoalveolar lavage fluid from wild type mice with airway inflammation contained mFPR2 agonist activity. This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses. The Journal of Immunology, 2010, 184: 3331-3335.
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