Journal
JOURNAL OF IMMUNOLOGY
Volume 186, Issue 3, Pages 1531-1537Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1001723
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Funding
- Institut Pasteur
- Maine de Paris
- Agence Nationale de la Recherche
- European Commission
- Deutsche Forschungsgemeinschaft
- Schlumberger Foundation
- Hanover Medical School
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Retinoic acid-related orphan receptor (ROR)gamma t(+) TCR alpha beta(+) cells expressing IL-17, termed Th17 cells, are most abundant in the intestinal lamina propria. Symbiotic microbiota are required for the generation of Th17 cells, but the requirement for microbiota-derived Ag is not documented. In this study, we show that normal numbers of Th17 cells develop in the intestine of mice that express a single TCR in the absence of cognate Ag, whereas the microbiota remains essential for their development. However, such mice, or mice monocolonized with the Th17-inducing segmented filamentous bacteria, fail to induce normal numbers of Foxp3(+) ROR gamma t(+) T cells, the regulatory counterpart of IL-17(+)ROR gamma t(+) T cells. These results demonstrate that a complex microbiota and cognate Ag are required to generate a properly regulated set of ROR gamma t(+) T cells and Th17 cells. The Journal of Immunology, 2011, 186: 1531-1537.
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