Journal
JOURNAL OF IMMUNOLOGY
Volume 185, Issue 5, Pages 2800-2807Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1000856
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Funding
- Medical Research Council
- Wellcome Trust
- Scientific Projects Committee
- Juvenile Diabetes Research Foundation
- MRC [G120/854, G0802382] Funding Source: UKRI
- Medical Research Council [G0802382, G120/854, G9818340B] Funding Source: researchfish
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The entry of autoreactive T cells into the pancreas is a critical checkpoint in the development of autoimmune diabetes. In this study, we identify a role for B1 cells in this process using the DO11 X RIP-mOVA mouse model. In transgenic mice with islet-specific T cells, but no B cells, T cells are primed in the pancreatic lymph node but fail to enter the pancreas. Reconstitution of the B1 cell population by adoptive transfer permits extensive T cell pancreas infiltration. Reconstituted B1 cells traffic to the pancreas and modify expression of adhesion molecules on pancreatic vasculature, notably VCAM-1. Despite substantial pancreas infiltration, islet destruction is minimal unless regulatory T cells are depleted. These data identify a role for B1 cells in permitting circulating islet-specific T cells to access their Ag-bearing tissue and emphasize the existence of multiple checkpoints to regulate autoimmune disease. The Journal of Immunology, 2010, 185: 2800-2807.
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