Journal
JOURNAL OF IMMUNOLOGY
Volume 183, Issue 7, Pages 4169-4175Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0901017
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- Department of Biotechnology, Government of India
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Inflammation appears to be a necessity for both metastasis and elimination of tumor cells. IL-17, a proinflammatory cytokine produced by Th17 cells, contributes to both the processes by playing a dual role in the antitumor immunity. On one hand, IL-17 promotes an antitumor cytotoxic T cell response leading to tumor regression. On the other hand, by facilitating angiogenesis and egress of tumor cells from the primary focus, IL-17 promotes tumor growth. Thus, the therapeutic application that uses IL-17 needs to be refined by minimizing its protumor functions. The Journal of Immunology, 2009, 183: 4169-4175.
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