Journal
JOURNAL OF IMMUNOLOGY
Volume 182, Issue 12, Pages 7838-7845Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0900382
Keywords
-
Categories
Funding
- National Institutes of Health [AI055743, AI073672]
Ask authors/readers for more resources
Pathogen-specific CD4 T cells are activated within a few hours of oral Salmonella infection and are essential for protective immunity. However, CD4 T cells do not participate in bacterial clearance until several weeks after infection, suggesting that Salmonella can inhibit or evade CD4 T cells that are activated at early time points. Here, we describe the progressive culling of initially activated CD4 T cells in Salmonella-infected mice. Loss of activated CD4 T cells was independent of early instructional programming, T cell precursor frequency, and Ag availability. In contrast, apoptosis of Ag-specific CD4 T cells was actively induced by live bacteria in a process that required Salmonella pathogenicity island-2 and correlated with increased expression of PD-L1. These data demonstrate efficient culling of initially activated Ag-specific CD4 cells by a microbial pathogen and document a novel strategy for bacterial immune evasion. The Journal of Immunology, 2009, 182: 7838-7845.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available