Journal
JOURNAL OF IMMUNOLOGY
Volume 183, Issue 5, Pages 2911-2914Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0901872
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Funding
- National Institutes of Health [AI068129]
- Cancer Research Institute
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI068129] Funding Source: NIH RePORTER
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NK cells respond rapidly during viral infection. The development, function, and survival of NK cells are thought to be dependent on IL-15. In mice lacking IL-15, NK cells are found in severely decreased numbers. Surprisingly, following infection of IL-15- and IL-15R alpha-deficient mice with mouse CMV, we measured a robust proliferation of Ly49H-bearing NK cells in lymphoid and nonlymphoid organs capable of cytokine secretion and cytolytic function. Remarkably, even in Rag2(-/-) x Il2rg(-/-) mice, a widely used model of NK cell deficiency, we detected a significant number of NK cells 1 wk after mouse CMV infection. In these mice we measured a >300-fold expansion of NK cells, which was dependent on recognition of the in 157 viral glycoprotein ligand and IL-12. Together, these findings demonstrate a previously unrecognized independence of NK cells on IL-15 or other common gamma signaling cytokines during their response against viral infection. The Journal of Immunology, 2009, 183:2911-2914.
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