4.8 Article

Pd(II)-Catalyzed P(O)R1R2-Directed Asymmetric C-H Activation and Dynamic Kinetic Resolution for the Synthesis of Chiral Biaryl Phosphates

Journal

ORGANIC LETTERS
Volume 17, Issue 8, Pages 2034-2037

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00844

Keywords

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Funding

  1. NSFC [21272100, 21472076]
  2. Program for New Century Excellent Talents in University [NCET-11-0215, lzujbky-2013-k07]

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An efficient method of Pd(II)-catalyzed P(O)-(RR2)-R-1-directed asymmetric C-H activation and dynamic kinetic resolution for synthesis of chiral phosphinate ligands has been performed and exhibits a wide scope of substrates and an excellent diastereomeric ratio (>95:5).

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