Journal
JOURNAL OF IMMUNOLOGY
Volume 182, Issue 4, Pages 2041-2050Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0803267
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Funding
- National Institutes of Health [R01AI052116]
- Leukemia and Lymphoma Society
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How T cells achieve rapid chemotactic motility tinder certain circumstances and efficient cell surface surveillance in others is not fully understood. We show that T lymphocytes are motile in two distinct modes: a fast amoeboid-like mode, which uses sequential discontinuous contacts to the substrate; and a slower mode using a single continuously translating adhesion, similar to mesenchymal motility. Myosin-IIA is necessary for fast amoeboid motility, and our data suggests that this occurs via cyclical rear-mediated compressions that eliminate existing adhesions while licensing subsequent ones at the front of the cell. Regulation of Myosin-IIA function in T cells is thus a key mechanism to regulate surface contact area and crawling velocity within different environments. This can provide T lymphocytes with motile and adhesive properties that are uniquely suited toward alternative requirements for immune surveillance and response. The Journal of Immunology, 2009, 182: 2041-2050.
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