Journal
JOURNAL OF IMMUNOLOGY
Volume 183, Issue 8, Pages 4833-4837Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0900968
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Funding
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development and Health, Services Research and Development [383]
- American Cancer Society postdoctoral fellowship [PF-07-067-01-LIB]
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B lymphocytes are a potential alternative to dendritic cell immunotherapy, with the advantages of relative abundance in peripheral blood and the ability to function as APCs. Although B cells express multiple receptors that induce costimulatory molecules, B cell vaccine studies have focused primarily on CD40 stimulation. To optimize the potential efficacy of B cell vaccines (Bvac), we compared the capacity of differentially stimulated B cells to induce Ag-specific CD8(+) T cell responses in vivo. CD40- or TLR7-stimulated B cell APCs induced similar CD8(+) T cell responses, but costimulation through the BCR and TLR7 produced a more effective Bvac as measured by T cell stimulation and the protection of mice from an infectious pathogen. This increased effectiveness depended upon enhanced production of IL-6 by BCR plus TLR7-stimulated B cells. These findings reveal alternative stimulation strategies for the production of effective Bvac and identify a key role for IL-6 in B cell Ag presentation and cellular vaccines. The Journal of Immunology, 2009, 183: 4833-4837.
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