Journal
JOURNAL OF IMMUNOLOGY
Volume 184, Issue 1, Pages 277-286Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0902373
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Funding
- National Institutes of Health [R01-EY05945, P30-EY08098, K23-A1064396]
- Research to Prevent Blindness
- Eye and Ear Foundation of Pittsburgh
- NATIONAL EYE INSTITUTE [P30EY008098, R01EY005945] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K23AI064396] Funding Source: NIH RePORTER
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HSV-specific CD8(+) T cells provide constant immunosurveillance of HSV-1 latently infected neurons in sensory ganglia, and their functional properties are influenced by the presence of latent virus. In this study, we show that ganglionic HSV-specific CD8(+) T cells exhibit a higher functional avidity (ability to respond to low epitope density) than their counterparts in noninfected lungs, satisfying a need for memory effector cells that can respond to low densities of viral epitopes on latently infected neurons. We further show that lack of CD4(+) T cell help during priming leads to a transient inability to control latent virus, which was associated with a PD-1/PD-L1 mediated reduced functional avidity of ganglionic HSV-specific CD8(+) T cells. CD4(+) T cells are not needed to maintain CD8(+) T cell memory through 34 d after infection, nor do they have a direct involvement in the maintenance of HSV-1 latency. The Journal of Immunology, 2010, 184: 277-286.
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