Journal
ORGANIC LETTERS
Volume 17, Issue 19, Pages 4850-4853Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02414
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- JST, ACT-C
- Asahi Glass Foundation
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We report here a method for direct catalytic introduction of simple alpha-acylalkyl groups via rhodium-catalyzed C-H functionalization with cyclic alkenyl carbonates, synthetic equivalents to enolates bearing leaving groups. The reaction proceeded smoothly without using bases to give a-aryl ketones in high yields. Various nitrogen-containing aromatic rings and amide groups serve as directing groups. 3-Substituted isocoumarins can also be prepared by one-pot C-H functionalization/cyclization.
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