Journal
JOURNAL OF IMMUNOLOGY
Volume 183, Issue 8, Pages 5085-5093Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0901884
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- NIH [R01-AR056632, R01-AR44077]
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Mice lacking epidermal Langerhans cells (LC) develop exaggerated contact-hypersensitivity (CHS) responses due to the absence of LC during sensitization/initiation. Examination of T cell responses reveals that the absence of LC leads to increased numbers of hapten-specific CD4 and CD8 T cells but does not alter cytokine expression or development of T regulatory cells. CHS responses and Ag-specific T cells are increased in mice in which MHC class II is ablated specifically in LC suggesting that direct cognate interaction between LC and CD4 cells is required for suppression. LC-derived IL-10 is also required for optimal inhibition of CHS. Both LC-derived IL-10-mediated suppression and full LC activation require LC expression of MHC class II. These data support a model in which cognate interaction of LC with CD4 T cells enables LC to inhibit expansion of Ag-specific responses via elaboration of IL-10. The Journal of Immunology, 2009, 183: 5085-5093.
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