4.8 Article

Nickel-Catalyzed Direct C (sp3)-H Arylation of Aliphatic Amides with Thiophenes

Journal

ORGANIC LETTERS
Volume 17, Issue 21, Pages 5228-5231

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02572

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Funding

  1. NSFC [21373003, 21273068, J1210040]
  2. Fundamental Research Funds for the Central Universities

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Nickel-catalyzed heteroarylation of the inactive methyl C(sp(3))-H bond of aliphatic amide with heteroarenes is described. The method takes advantage of chelation assistance by an 8-aminoquinolinyl moiety. The synthetic reaction has good tolerance toward functional groups, and it can be used in the construction of various hinds of alkyl-substituted heteroarenes.

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