4.8 Article

Cobalt Catalyzed C-H and N-H Bond Annulation of Sulfonamide with Terminal and Internal Alkynes

Journal

ORGANIC LETTERS
Volume 17, Issue 24, Pages 6118-6121

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03142

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Funding

  1. Indian Institute of Technology Kanpur [IITK/CHM/20130187]
  2. DAE-BRNS [BRNS/CHM/2014110]
  3. IITK

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Chelate assisted cobalt catalyzed C-H and N-H annulation of aryl sulfonamide with terminal and internal ales is reported. Very high regioselectivity and excellent functional group tolerance were achieved using Oxygen as a co-oxidant. The reaction is scalable under mild conditions.

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