Journal
JOURNAL OF IMMUNOLOGY
Volume 182, Issue 2, Pages 759-765Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.182.2.759
Keywords
-
Categories
Funding
- National Institute on Aging at the National Institutes of Health
Ask authors/readers for more resources
Pre-TCR and IL-7R signals regulate beta-selection of thymocytes and then must be down-regulated for further development. However, the molecular events that control down-regulation remain unknown. We and others have previously shown that beta-catenin in cooperation with TCF regulates beta-selection. In this paper, we demonstrate that beta-catenin expression is stringently regulated by intrathymic signals, it is expressed at the highest levels in the pre-TCR signaled thymocytes, and is down-regulated in post-beta-selection thymocytes. Pre-TCR-induced beta-catenin regulates initial stages of pre-TCR signaling including expression of early growth response (Egr) genes but must be down-regulated to express ROR gamma t, which is essential for maturation to the CD4(+)CD8(+) double positive (DP) stage. Sustained expression of beta-catenin results in the generation of IL-7R-, Egr-, and TGF beta-expressing pre-DP thymocytes that are blocked in development. These data are consistent with a model in which post-beta-selection, pre-TCR-induced beta-catenin expression must return to background levels for efficient transition to the DP stage. The Journal of Immunology, 2009, 182: 759-765.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available