Journal
JOURNAL OF IMMUNOLOGY
Volume 183, Issue 5, Pages 2915-2920Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0801607
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Funding
- Roche Pharmaceuticals
- Cardiff and Vale National Health Service Trust Research and Development department
- Medical Research Council Senior Fellow
- MRC [G117/488] Funding Source: UKRI
- Medical Research Council [G117/488] Funding Source: researchfish
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Despite its use widely as a therapeutic agent, and proposed use as vaccine adjuvant, the effect of IFN alpha on T cell function is poorly understood. As a pleiotropic innate cytokine produced rapidly in response to pathogens, it is well placed to impinge on specific immune responses. The aim of this study was to examine the impact of IFN alpha on the function of human memory CD4(+) T cells using the recall Ags purified protein derivative, tetanus toxoid, and hemagglutinin. IFN alpha administered either in vivo or added exogenously in vitro tended to enhance proliferative responses of purified protein derivative-specific T cells in marked contrast to the other cognate populations whose responses were often diminished. Purifying the memory CD4(+)CD45RO(+) T cells confirmed IFN alpha acted directly on these cells and not via an intermediate. The T cells could be divided into two broad categories depending on how IFN alpha effected their responses to cognate Ag: 1) enhanced proliferation and a striking increase in IFN gamma-production compared with smaller increases in IL-10 (increased ratio of IFN gamma:IL-10), and 2) neutral or diminished proliferation coupled with a smaller increase in IFN gamma relative to the increase in IL-10 (reduced IFN gamma:IL-10 ratio). IFN alpha has a role in modifying memory T cell responses when they are exposed to cognate Ag and may be important in vaccination strategies designed to augment particular Th memory responses. The Journal of Immunology, 2009, 183: 2915-2920.
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