Journal
ORGANIC LETTERS
Volume 17, Issue 5, Pages 1332-1335Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00340
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Funding
- NIH [GM069559]
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The development of a method for the Rh(III)-catalyzed direct vinylation of an aromatic C-H bond to give functionalized styrenes in good yield, using vinyl acetate as a convenient and inexpensive vinyl source, is reported. High functional group tolerance is demonstrated for electronically distinct arenes as well as different directing groups. Mechanistic investigation resulted in the characterization of a novel rhodium-metallacycle, which represents the first X-ray structure of a [1,2]-Rh(III)-alkenyl addition adduct.
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