Journal
ORGANIC LETTERS
Volume 17, Issue 24, Pages 6034-6037Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03035
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Funding
- 973 Program [2012CB725302]
- National Natural Science Foundation of China [21390400, 21520102003, 21272180, 21302148]
- Hubei Province Natural Science Foundation of China [2013CFA081]
- Research Fund for the Doctoral Program of Higher Education of China [20120141130002]
- Ministry of Science and Technology of China [2012YQ120060]
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A novel strategy was developed to trigger center dot CF3 by using in situ generated peroxide in NMP under O-2 or air as the radical initiator. Radical trifluoromethylation of alkenes was achieved toward tertiary beta(-)trifluoromethyl alcohols. Various tertiary beta-trifluoromethyl alcohols can be synthesized in good yields without extra oxidants or transition metal catalysts. Preliminary mechanistic investigation revealed that O-2 diffusion can influence the reaction rate.
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