Journal
ORGANIC LETTERS
Volume 17, Issue 4, Pages 964-967Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00067
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [TBAG-112 T360, TBAG 113Z901]
- Turkish Academy of Sciences (TUBA)
- Middle East Technical University (METU)
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A concise and regioselective approach to the synthesis of chromenopyridine and chromenopyridinone derivatives was developed. The synthetic strategy relies on the O-propargylation of aromatic hydroxyaldehydes followed by reaction with propargylamine. The intramolecular cycloaddition reaction between the alkyne and azadiene, which is formed as an intermediate, furnished the desired skeletons.
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