Journal
JOURNAL OF IMMUNOLOGY
Volume 181, Issue 4, Pages 2265-2270Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.4.2265
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Funding
- NIAID NIH HHS [R01 AI039560-13, R01 AI 39560, R01 AI039560, T32 AI007313] Funding Source: Medline
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The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 alpha/beta T cells, gamma/delta T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus and must leave it to provide their functions elsewhere in the body. This article will review recent research indicating differences in the time and migration patterns of T cell subsets found in the thymus. Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P(1) and its regulation by the Kruppel-like transcription factor KLF2.
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