Journal
JOURNAL OF IMMUNOLOGY
Volume 181, Issue 12, Pages 8761-8766Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.12.8761
Keywords
-
Categories
Funding
- National Institutes of Health [RO1 AI42269, RO1 AI49954]
- Mary Kirkland Center
- Hospital for Special Surgery
Ask authors/readers for more resources
Double negative (DN) T cells are expanded in patients with systemic lupus erythematosus (SLE) and stimulate autoantibody production as efficiently as CD4(+) T cells. In this study, we demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and IFN-gamma, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of accessory cells. Furthermore, IL-17(+) and DN T cells are found in kidney biopsies of patients with lupus nephritis. Our findings establish that DN T cells produce the inflammatory cytokines IL-17 and IFN-gamma, and suggest that they contribute to the pathogenesis of kidney damage in patients with SLE. The Journal of Immunology, 2008, 181: 8761-8766.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available