Journal
JOURNAL OF IMMUNOLOGY
Volume 180, Issue 11, Pages 7404-7413Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.180.11.7404
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- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM062116] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM62116] Funding Source: Medline
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The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-alpha by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nouredundant role in the induction of inflammatory signaling in response to C. albicans infection.
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