4.8 Article

LDA-Mediated Synthesis of Triarylmethanes by Arylation of Diarylmethanes with Fluoroarenes at Room Temperature

Journal

ORGANIC LETTERS
Volume 17, Issue 20, Pages 5096-5099

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02602

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Funding

  1. National Natural Science Foundation of China [21472043, 21272070]

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A practical and convenient approach for the secondary C(sp(3))-H arylation of diarylmethanes with various fluoroarenes is described. The reaction proceeds smoothly in the presence of LDA (lithium diisopropylamide) at room temperature and affords triarylmethanes in moderate to high yields.

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