Journal
ORGANIC LETTERS
Volume 17, Issue 19, Pages 4874-4877Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02432
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Funding
- National Natural Science Foundation of China [21272148, 21472121, 21272147]
- State Key Laboratory of Applied Organic Chemistry, Lanzhou University
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An unusual multiple isocyanide insertion reaction with methyleneindolinone using indium(III) chloride as the catalyst has been disclosed. This strategy allows for the rapid construction of structurally complex spirooxindole in an efficient manner. The present protocol features mild conditions, atom economy, and broad substrate scope.
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