Journal
JOURNAL OF IMMUNOLOGY
Volume 181, Issue 8, Pages 5242-5248Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.8.5242
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Funding
- National Institutes of Health [R01 CA116092, R01CA107181, R01AT004294]
- Birmingham Veterans Administration Medical Center Merit Review
- Susan G. Komen Breast Cancer Foundation
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Exosomes released from different types of cells have been proposed to contribute to intercellular communication. We report that thymic exosome-like particles (ELPs) released from cells of the thymus can induce the development of Foxp3(+) regulatory T (Treg) cells in the lung and liver. Thymic ELPs also induce the conversion of thymic CD4(+)CD25(-) T cells into Tregs. Tregs induced by thymic ELPs suppress the proliferation of CD4(+)CD25(-) T cells in vitro and in vivo. We further show that neutralization of TGF-beta in ELPs partially reverses thymic ELP-mediated induction of CD4(+)Foxp3(+) T cells in the lung and liver. This study demonstrates that thymic ELPs participate in the induction of Foxp3(+) Tregs. Also, TGF-beta of thymic ELPs might be required for the generation of Tregs in the peripheral tissues.
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