Journal
JOURNAL OF IMMUNOLOGY
Volume 180, Issue 10, Pages 6868-6876Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.180.10.6868
Keywords
-
Categories
Funding
- Intramural NIH HHS [Z01 BC009369-16, NIH0012494754] Funding Source: Medline
- NCI NIH HHS [N01CO12400, N01 CO 12400] Funding Source: Medline
Ask authors/readers for more resources
Lactoferrin is an 80-kDa iron-binding protein present at high concentrations in milk and in the granules of neutrophils. It possesses multiple activities, including antibacterial, antiviral, antifungal, and even antitumor effects. Most of its antimicrobial effects are due to direct interaction with pathogens, but a few reports show that it has direct interactions with cells of the immune system. In this study, we show the ability of recombinant human lactoferrin (talactoferrin alfa (TLF)) to chemoattract monocytes. What is more, addition of TLF to human peripheral blood or monocyte-derived dendritic cell cultures resulted in cell maturation, as evidenced by up-regulated expression of CD80, CD83, and CD86, production of proinflammatory cytokines, and increased capacity to stimulate the proliferation of allogeneic lymphocytes. When injected into the mouse peritoneal cavity, lactoferrin also caused a marked recruitment of neutrophils and macrophages. Immunization of mice with OVA in the presence of TLF promoted Thl-polarized Ag-specitic immune responses. These results suggest that lactoferrin contributes to the activation of both the innate and adaptive immune responses by promoting the recruitment of leukocytes and activation of dendritic cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available