4.6 Article

B and T lymphocyte attenuator regulates T cell survival in the lung

Journal

JOURNAL OF IMMUNOLOGY
Volume 181, Issue 5, Pages 2973-2979

Publisher

AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.5.2973

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Funding

  1. National Institutes of Health [HL062683, U19 AI070489]
  2. Howard Hughes Medical Institute [T32 HL07317]

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The initiation, intensity, and duration of T cell-directed inflammatory responses are dependent upon the coordination of both activating and inhibitory signals mediated by specific receptors on the T lymphocyte. The recently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an important role in limiting the duration of inflammation in a murine model of allergic asthma. In this study, we have examined the role of BTLA on the proliferation, recruitment, and survival of T cells in response to inhaled allergen. We find that there is decreased cell death in T cells from BTLA-deficient mice, whereas proliferation and recruitment to the lungs are unchanged. Thus, the regulation of cell death through BTLA signaling is a key determinant of the inflammatory response in the lung.

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