Journal
ORGANIC LETTERS
Volume 18, Issue 2, Pages 244-247Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02964
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Funding
- National Natural Science Foundation of China [21372208]
- Shandong Provincial Natural Science Fund for Distinguished Young Scholars [JQ201422]
- Program for New Century Excellent Talents in University [NCET-12-0499]
- National High Technology Research and Development Program of China [2013AA092901]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
- Fundamental Research Funds for the Central Universities
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Neosartoryadins A (1) and B (2), both with a unique 6/6/6/5 quinazoline ring system connected directly to a 6/5/5 imidazoindolone ring, together with three biogenetically related compounds 3-5, were isolated from the endophytic fungus Neosartorya udagawae HDN13-313. The absolute configurations of new compounds 1-4 were established. Compounds 1 and 2 displayed anti-influenza virus A (H1N1) activities with IC50 values of 66 and 58 mu M, respectively (ribavirin as positive control, IC50 = 94 mu M).
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