4.8 Article

Neosartoryadins A and B, Fumiquinazoline Alkaloids from a Mangrove-Derived Fungus Neosartorya udagawae HDN13-313

Journal

ORGANIC LETTERS
Volume 18, Issue 2, Pages 244-247

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02964

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Funding

  1. National Natural Science Foundation of China [21372208]
  2. Shandong Provincial Natural Science Fund for Distinguished Young Scholars [JQ201422]
  3. Program for New Century Excellent Talents in University [NCET-12-0499]
  4. National High Technology Research and Development Program of China [2013AA092901]
  5. NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
  6. Fundamental Research Funds for the Central Universities

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Neosartoryadins A (1) and B (2), both with a unique 6/6/6/5 quinazoline ring system connected directly to a 6/5/5 imidazoindolone ring, together with three biogenetically related compounds 3-5, were isolated from the endophytic fungus Neosartorya udagawae HDN13-313. The absolute configurations of new compounds 1-4 were established. Compounds 1 and 2 displayed anti-influenza virus A (H1N1) activities with IC50 values of 66 and 58 mu M, respectively (ribavirin as positive control, IC50 = 94 mu M).

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