Journal
ORGANIC LETTERS
Volume 17, Issue 10, Pages 2322-2325Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00730
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Funding
- National Science Foundation of China [21202168, 21472190]
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The title reaction proceeds with acetylenic triflones and isocyanides under mild conditions using copper as a catalyst. This transformation provides an efficient access to (E)-N-alkyl trifluoromethyl alkynyl ketoimines, which are useful building blocks for the synthesis of CF3-containing N-heterocycles, propargylamines, etc.
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