Journal
ORGANIC LETTERS
Volume 17, Issue 14, Pages 3556-3559Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01650
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Funding
- University of Hawaii Cancer Center
- Victoria S. and Bradley L. Geist Foundation [15ADVC-74420]
- U.S. Department of Agriculture, Agricultural Research Service Specific Cooperative Agreement [58-6408-2-0009]
- ARS [ARS-0428996, 813738] Funding Source: Federal RePORTER
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An endophytic fungus Paraphaeosphaeria neglecta FT462 isolated from the Hawaiian-plant Lycopodiella cernua (L.) Pic. Serm produced one unusual compound (1, paraphaeosphaeride A) with the 4-pyranone-gamma-lactam-1,4-thiazine moiety, along With two new compounds (2 and 3, paraphaeosphaerides B and C, respectively) and the known compound (4). Compounds 1-3 were characterized by NMR and MS spectroscopic analysis. The absolute configuration of the 3-position of compound 1 was determined as S by electronic circular dichroism (ECD) calculations. Compound 3 also Showed STAT3 inhibition at 10 mu M.
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