Journal
ORGANIC LETTERS
Volume 17, Issue 10, Pages 2318-2321Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00726
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Funding
- NSFC [21302032, 21302033, 21373073]
- PCSIRT [IRT 1231]
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A chiral N-heterocyclic carbene (NHC)-catalyzed [3 + 3] cycloaddition reaction of imines and oxindole-derived enals was developed for rapid access to spirocylic oxindoles. In most cases, the desired spirocylic oxindole products were obtained in high yields and excellent enantioselectivities with less than 1 h of reaction time.
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