Journal
JOURNAL OF IMMUNOLOGY
Volume 180, Issue 12, Pages 8393-8399Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.180.12.8393
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Funding
- NINDS NIH HHS [R01 NS037570-11, R01 NS037570-12, R01 NS037570-10, R01 NS037570, R01 NS 37570-01A2] Funding Source: Medline
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The activation of Ag-specific T cells locally in the CNS could potentially contribute to the development of immune-mediated brain diseases. We addressed whether Ag-specific T cells could be stimulated in the CNS in the absence of peripheral lymphoid tissues by analyzing Ag-specific T cell responses in organotypic brain slice cultures. Organotypic brain slice cultures were established 1 h after intracerebral OVA Ag microinjection. We showed that when OVA-specific CD8(+) T cells were added to Ag-containing brain slices, these cells became activated and migrated into the brain to the sites of their specific Ags. This activation of OVA-specific T cells was abrogated by the deletion of CD11c(+) cells from the brain slices of the donor mice. These data suggest that brain-resident CD11c(+) cells stimulate Ag-specific naive CD8(+) T cells locally in the CNS and may contribute to immune responses in the brain.
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