4.8 Article

Palladium-Catalyzed C-H Arylation of (Benzo)oxazoles or (Benzo)thiazoles with Aryltrimethylammonium Triflates

Journal

ORGANIC LETTERS
Volume 17, Issue 19, Pages 4926-4929

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02458

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Funding

  1. National Natural Science Foundation of China [21372212]
  2. National Basic Research Program of China [2015CB856600]

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The C-H arylation of (benzo)oxazoles or (benzo)thiazoles with aryltrimethylammonium triflates was carried out via Pd-catalyzed C-H/C-N cleavage. Oxazoles, thiazoles, benzoxazole, and benzothiazole were arylated using activated and deactivated aryltrimethylamrnonium triflates to give 2-aryl(benzo)oxazoles or 2-aryl(benzo)thiazoles in reasonable to excellent yields.

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