Journal
ORGANIC LETTERS
Volume 17, Issue 18, Pages 4608-4611Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02351
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Funding
- National Natural Science Foundation of China
- National Basic Research Program of China (973 Program) [2014CB745100]
- Tianjin Municipal Science & Technology Commission [14JCZDJC33400]
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An organocatalytic asymmetric Mannich reaction of allylic ketones with cyclic N-sulfonyl alpha-iminoester has been developed. By using a saccharide-derived chiral tertiary amino-thiourea catalyst, a range of allylic ketones and N-sulfonyl ketimines reacted smoothly to afford tetrasubstituted alpha-amino esters in high yields with good to excellent regio-, diastero-, and enantioselectivities.
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