Journal
ORGANIC LETTERS
Volume 17, Issue 11, Pages 2748-2751Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01156
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- Fonds der Chemischen Industrie (FCI)
- Deutsche Forschungsgemeinschaft (DFG)
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A new selenium-catalyzed protocol for the direct, intramolecular amination of C(sp(2))-H bonds using N-fluorobenzenesulfonimide as the terminal oxidant is reported. This method enables the facile formation of a broad range of diversely functionalized indoles and azaindoles derived from easily accessible ortho-vinyl anilines and vinylated aminopyridines, respectively. The procedure exploits the pronounced carbophilicity of selenium electrophiles for the catalytic activation of alkenes and leads to the formation of C(sp(2))-N bonds in high yields and with excellent functional group tolerance.
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