Journal
ORGANIC LETTERS
Volume 17, Issue 5, Pages 1308-1311Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00311
Keywords
-
Categories
Funding
- National Science Foundation of China [21472151]
Ask authors/readers for more resources
A new method has been developed for the catalytic enantioselective 1,3-dipolar cycloaddition of the Seyferth-Gilbert reagent (SGR) to isatylidene malononitriles using a cinchona alkaloid derivative as a catalyst. This method allowed for the synthesis of a series of chiral spiro-phosphonylpyrazoline-oxindoles in good yields with excellent enantioselectivities. The synthetic utility of this method was further demonstrated by its use in a three-component domino reaction involving isatin, malononitrile, and SGR based on sequential Knoevenagel condensation and 1,3-dipolar cycloaddition reactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available