Journal
JOURNAL OF IMMUNOLOGICAL METHODS
Volume 410, Issue -, Pages 100-112Publisher
ELSEVIER
DOI: 10.1016/j.jim.2014.03.022
Keywords
Fungus; Animal model; Mouse; Immune response; Pathogenesis; Yeast
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Funding
- Robert Sinskey Foundation
- NIH [RO1 AI093808, R21 AI105617]
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Fungi represent emerging infectious threats to human populations worldwide. Mice and other laboratory animals have proved invaluable in modeling clinical syndromes associated with superficial and life-threatening invasive mycoses. This review outlines salient features of common vertebrate animal model systems to study fungal pathogenesis, host antifungal immune responses, and antifungal compounds. (C) 2014 Elsevier B.V. All rights reserved.
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