4.2 Article

Malaria infections: What and how can mice teach us

Journal

JOURNAL OF IMMUNOLOGICAL METHODS
Volume 410, Issue -, Pages 113-122

Publisher

ELSEVIER
DOI: 10.1016/j.jim.2014.05.001

Keywords

Plasmodium; Malaria; Host; Rodent models; Pathology; Infection

Funding

  1. FCT fellowship [SFRH/BPD/81953/2011]

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Malaria imposes a horrific public health burden - hundreds of millions of infections and millions of deaths - on large parts of the world. While this unacceptable health burden and its economic and social impact have made it a focal point of the international development agenda, it became consensual that malaria control or elimination will be difficult to attain prior to gain a better understanding of the complex interactions occurring between its main players: Plasmodium, the causative agent of disease, and its hosts. Practical and ethical limitations exist regarding the ability to carry out research with human subjects or with human samples. In this review, we highlight how rodent models of infection have contributed significantly during the past decades to a better understanding of the basic biology of the parasite, host response and pathogenesis. (C) 2014 Elsevier B.V. All rights reserved.

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