Journal
ORGANIC LETTERS
Volume 17, Issue 18, Pages 4498-4501Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02175
Keywords
-
Categories
Funding
- Comite des Pyrenees Orientales de la Ligue Nationale Contre le Cancer and the BQR de l'Universite de Perpignan Via Domitia
Ask authors/readers for more resources
A concise synthetic pathway yielding to hydrophobic alpha,alpha-disubstituted disilylated amino acids based on a hydrosilylation reaction is described. As a first example of utilization in solid-phase peptide synthesis, TESDpg was introduced in replacement of Aib in an alamethicin sequence, leading to analogues with modified physicochemical properties and conserved helical structures. This study highlights the potential of these new amino acids as tools for peptide modulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available