Journal
JOURNAL OF IMMUNOLOGICAL METHODS
Volume 374, Issue 1-2, Pages 62-69Publisher
ELSEVIER
DOI: 10.1016/j.jim.2010.10.010
Keywords
Epitope conservation; Epitope predictions; Vaccine design; Major Histocompatibility Complex
Categories
Funding
- National Institutes of Health's (National Institute of Allergy and Infectious Disease) [HHSN26620040006C]
Ask authors/readers for more resources
The Immune Epitope Database and Analysis Resource (IEDB, http://www.iedb.org) hosts a continuously growing set of immune epitope data curated from the literature, as well as data submitted directly by experimental scientists. In addition, the IEDB hosts a collection of prediction tools for both MHC class I and II restricted T-cell epitopes that are regularly updated. In this review, we provide an overview of T-cell epitope data and prediction tools provided by the IEDB. We then illustrate effective use of these resources to support experimental studies. We focus on two applications, namely identification of conserved epitopes in novel strains of a previously studied pathogen, and prediction of novel T-cell epitopes to facilitate vaccine design. We address common questions and concerns faced by users, and identify patterns of usage that have proven successful. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available