Journal
ORGANIC LETTERS
Volume 17, Issue 21, Pages 5180-5183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02484
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Funding
- National Nature Science Foundation of China [20972051, 21476078, 08431901800, 08430703900]
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A novel one-pot efficient synthesis of 2,5-dihydro-1H-benzo[c]azepines and 10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a]azepines from alpha-amino acids and aromatic aldehydes containing an ortho-Michael acceptor is reported via decarboxylative annulations without metal catalysts in yields of 52-91%. Under microwave irradiation, this protocol provides rapid access to polycyclic ring systems (only 5 min in most cases).
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