Journal
JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY
Volume 31, Issue 2, Pages 148-159Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15321811003617453
Keywords
cytokine; human blood cultures; immunotoxicity; molasses; sugar cane
Funding
- National Research Foundation of South Africa
- DAAD (Deutscher Akademishcer Austausch Dienst) foundation in Germany
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This study investigated the effects of sugar cane molasses on the immune system, using cytokines as biomarkers. Whole blood cultures, stimulated in vitro with endotoxin or PHA, were incubated with various concentrations of molasses. No cell death occurred in whole blood cultures incubated with molasses samples. The addition of molasses (800 mu g/mL) to unstimulated whole blood cultures resulted in increased levels of the biomarker of inflammation, Interleukin-6 (P < 0.001) and also the biomarker of humoral immunity, Interleukin-10 (P < 0.001). Molasses addition (800 mu g/mL) to unstimulated whole blood cultures has no effect on the cell mediated immunity biomarker, Interferon gamma secretion. Molasses has no effect on Interleukin-6, Interleukin-10 and Interferon gamma secretion in stimulated whole blood cultures. Immunostimulation by molasses requires further investigation as it may have potential health impacts.
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