4.8 Article

Total Synthesis of (-)-N-Methylwelwitindolinone C Isothiocyanate Based on a Pd-Catalyzed Tandem Eno late Coupling Strategy

Journal

ORGANIC LETTERS
Volume 17, Issue 15, Pages 3918-3921

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01952

Keywords

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Funding

  1. JSPS [25253002]
  2. MEXT [2304, 24105526]
  3. Grants-in-Aid for Scientific Research [26105747, 25253002, 15K07861, 24105526] Funding Source: KAKEN

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The highly stereocontrolled total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate is described, which features the expeditious construction of a bicyclo[4.3.1]decane ring system by a palladium-catalyzed tandem enolate allylation/arylation reaction.

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